Cardiovascular Gene Ontology Annotation Initiative
 This initiative (www.ucl.ac.uk/cardiovasculargeneontology), headed by Prof. Philippa Talmud, represents a collaboration between University College London and the European Bioinformatics Institute (EBI), funded by the British Heart Foundation.
The Gene Ontology (GO) vocabulary is the established standard for the functional annotation of gene products. By using GO to curate scientific literature and by integrating results from high-quality high-throughput experiments we will create an information-rich resource for the cardiovascular-research community, enabling researchers to rapidly evaluate and interpret existing data and generate hypotheses to guide future research.
Cardiovascular Annotation Committee
| Chair |
Professor Philippa Talmud, Head of Lipid Subgroup, Centre for Cardiovascular Genetics, Division of Medicine, UCL. |
| Collaborators |
Dr Rolf Apweiler, Joint Team Leader PANDA group, EBI.
Professor Peter Scambler, Theme leader, Genes, Development and Disease, Institute of Child Health, UCL.
Dr Mike Hubank, Senior Lecturer, Molecular Haematology and Cancer Biology Unit, Institute of Child Health, UCL. |
| GO annotators |
Dr Ruth Lovering
Dr Varsha Khodiyar |
| UniProt-GOA programmer |
Tony
Sawford
|
Over 4000 cardiovascular-associated genes have been identified as targets for annotation with GO terms. From this extensive cardiovascular-associated list genes are being prioritised for annotation, in close consultation with an expert advisory panel, based on criteria such as the volume of biomedical literature available, involvement in cardiovascular processes or disease and requests from the cardiovascular community.
The full list of cardiovascular target genes is shown below, for
prioritised genes, please click here
. If you have
any suggestions for additional targets, please email goa@ebi.ac.uk or GOAnnotations@ucl.ac.uk.
The UniProt-GOA group produces, in collaboration with the Cardiovascular GO Annotation Initiative, a BHF-UCL gene association file, which contains all GO annotations for over 4,000 human proteins implicated in cardiovascular development or disease. The BHF-UCL file is a sub-set of the UniProt gene association file, and will provide the cardiovascular community with a discrete set of relevant GO annotations. This file will be updated by UniProt-GOA monthly and can be downloaded from ftp://ftp.ebi.ac.uk/pub/databases/GO/GOA/bhf-ucl/gene_association.goa_bhf-ucl.gz
| Notes |
To search this target list use control F to display the search option in the bottom of the web browser, and then type your gene of interest in this field.
To view the GO terms associated with a protein click on the UniProtKB accession displayed in the table
To view the genes which have been prioritised for annotation in year 1 of this initiative, please click here. |
| 