Alzheimer's Gene Ontology Annotation Initiative

Alzheimer's Gene Ontology Annotation Initiative

This initiative (http://www.ucl.ac.uk/functional-gene-annotation/neurological), led by Dr Ruth Lovering, represents collaboration between University College London, the European Bioinformatics Institute (EBI), and University of Manchester, funded by Alzheimer’s Research UK.

The Gene Ontology (GO) vocabulary is the accepted standard for the functional annotation of proteins. By using GO to curate scientific literature and by integrating results from high-throughput experiments we are creating an information-rich resource for the Alzheimer’s research community, enabling researchers to rapidly evaluate and interpret existing data and generate hypotheses to guide future research.

 

People involved:

Principal Investigator Dr Ruth Lovering, Centre for Cardiovascular Genetics, Institute of Cardiovascular Science, UCL.
Co-applicants Professor Nigel M. Hooper, Division of Neuroscience and Experimental Psychology, School of Biological Sciences, University of Manchester.
GO annotators Dr Ruth Lovering, Dr Barbara Kramarz
Collaborators Dr Maria Martin, Protein Function Development, EMBL-EBI.

Professor Paul Whiting, Alzheimer's Research UK, UCL Drug Discovery Institute, UCL.
Professor Judith Blake, The Jackson Laboratory.

 

Target List

During the next six-months proteins shown to bind to amyloid-beta, listed in Table 1 in PMID:26719327 (Jarosz-Griffiths et al., 2016), will be prioritised for annotation by the Alzheimer's Gene Ontology Annotation Initiative.

The prioritised proteins are available as a combined list and can be used as a filter option in the QuickGO browser Gene Product ID tab (ARUK-UCL).

Jarosz-Griffiths, H. H., Noble, E., Rushworth, J. V. and Hooper, N. M. (2016) Amyloid-β Receptors: The Good, the Bad, and the Prion Protein. J Biol Chem 291(7), 3174-3183

UniProt-GOA collaborates with

Cardiovascular Gene Ontology Annotation Initiative DictyBase Ensembl Compara Enzyme Nomenclature FlyBase  GO Consortium logo GUDMAP Gramene HAMAP HGNC HPA IntAct InterPro LIFEdb MGI MTBbase logo Reactome RI RGD SGD SwissProt TAIR TIGR WormBase ZFIN The Evidence & Conclusion Ontology