Query examples - apoptosis, GO:0006915, tropomyosin, P06727.

Gene Ontology Annotation (GOA) Database

The GOA project aims to provide high-quality Gene Ontology (GO) annotations to proteins in the UniProt Knowledgebase (UniProtKB) and International Protein Index (IPI) and is a central dataset for other major multi-species databases; such as Ensembl and NCBI.

GOA has been a member of the GO Consortium since 2001, and is responsible for the integration and release of GO annotations to the human, chicken and cow proteomes. Because of the multi-species nature of the UniProtKB, GOA also assists in the curation of another 200,000 species. This involves electronic annotation and the integration of high-quality manual GO annotation from all GO Consortium model organism groups and specialist groups. This effort ensures that the GOA dataset remain a key reference and a comprehensive source of GO annotation for all species.

For fast access to the Gene Ontology terms and annotations, please use our QuickGO browser.

See who uses GO and GOA

Latest GOA news

GOA News Feed

All the latest news and information relating to GOA.

Date	GOA News
04 March, 2010	It is intended that the contents of column 1 in UniProtKB-GOA gene association files will change at our next monthly release. Currently column 1 displays the values 'UniProtKB/TrEMBL' or 'UniProtKB/Swiss-Prot' to indicate which section of UniProtKB an accession is a member (please see our readme for further information on our annotation format: http://www.ebi.ac.uk/GOA/goaHelp.html). However, these two different UniProtKB descriptions have caused processing issues for GO Consortium tools. Therefore we are intending that information on whether a protein is a member of the UniProtKB Swiss-Prot or TrEMBL sets will be provided to users in a tab-separated, supplementary gene product information file that will be released alongside UniProtKB-GOA gene association files, and column 1 will be changed to consistently display 'UniProtKB' for all UniProtKB accessions. Please contact us if you have any concerns regarding this format change.
18 December, 2009	We are pleased to announce that this release of GOA gene association files includes manual annotations created by the EcoCyc and EcoWiki groups.
30 November, 2009	We are pleased to announce that this release of GOA gene association files excludes annotations that apply a secondary or obsolete UniProtKB accession number in either column 2 (DB_Object_ID) or column 8 (With). This has meant that 3,929 (4.5%) manual annotations integrated from external annotation groups have been filtered from GOA files. We are working closely with all collaborating databases to help ensure that their set of UniProtKB accessions are regularly updated to valid primary UniProtKB accessions.

GOA News Archive

Latest GOA releases

GOA News Feed

Date	GOA Release
04 March, 2010	GOA UniProt 80 Released Version 80 UniProt GO annotation has been released. GOA Human 82 Released Version 82 of human GOA has been released. GOA Mouse 68 Released Version 68 of mouse GOA has been released. GOA Rat 68 Released Version 68 of rat GOA has been released. GOA Arabidopsis 55 Released Version 55 of arabidopsis GOA has been released. GOA Zebrafish 55 Released Version 55 of zebrafish GOA has been released. GOA Chicken 52 Released Version 52 of chicken GOA has been released. GOA Cow 45 Released Version 45 of cow GOA has been released. GOA PDB 69 Released GOA Proteome Sets 57 Released We are pleased to introduce GO annotation to 1983 proteome sets in this release. For information please follow this link.
21 January, 2010	GOA UniProt 79 Released Version 79 UniProt GO annotation has been released. GOA Human 81 Released Version 81 of human GOA has been released. GOA Mouse 67 Released Version 67 of mouse GOA has been released. GOA Rat 67 Released Version 67 of rat GOA has been released. GOA Arabidopsis 54 Released Version 54 of arabidopsis GOA has been released. GOA Zebrafish 54 Released Version 54 of zebrafish GOA has been released. GOA Chicken 51 Released Version 51 of chicken GOA has been released. GOA Cow 44 Released Version 44 of cow GOA has been released. GOA PDB 68 Released GOA Proteome Sets 56 Released We are pleased to introduce GO annotation to 1914 proteome sets in this release. For information please follow this link.
18 December, 2009	GOA UniProt 78 Released Version 78 UniProt GO annotation has been released. GOA Human 80 Released Version 80 of human GOA has been released. GOA Mouse 66 Released Version 66 of mouse GOA has been released. GOA Rat 66 Released Version 66 of rat GOA has been released. GOA Arabidopsis 53 Released Version 53 of arabidopsis GOA has been released. GOA Zebrafish 53 Released Version 53 of zebrafish GOA has been released. GOA Chicken 50 Released Version 50 of chicken GOA has been released. GOA Cow 43 Released Version 43 of cow GOA has been released. GOA PDB 67 Released GOA Proteome Sets 55 Released We are pleased to introduce GO annotation to 1880 proteome sets in this release. For information please follow this link.
30 November, 2009	GOA UniProt 77 Released Version 77 UniProt GO annotation has been released. GOA Human 79 Released Version 79 of human GOA has been released. GOA Mouse 65 Released Version 65 of mouse GOA has been released. GOA Rat 65 Released Version 65 of rat GOA has been released. GOA Arabidopsis 52 Released Version 52 of arabidopsis GOA has been released. GOA Zebrafish 52 Released Version 52 of zebrafish GOA has been released. GOA Chicken 49 Released Version 49 of chicken GOA has been released. GOA Cow 42 Released Version 42 of cow GOA has been released. GOA PDB 66 Released GOA Proteome Sets 54 Released We are pleased to introduce GO annotation to 1876 proteome sets in this release. For information please follow this link.

GOA Release Archive

Funding

Current Funding:

EMBL
NIH grant number R01HG02273-02: Gene Ontology Consortium
British Heart Foundation grant (SP:07/007/23671) 'The Integration of the knowledge if genes involved in heart development and cardiovascular processes from biomedical research, using standardised Gene Ontology'
Kidney Research UK Project Grant RP26/2008 - 'Integration of knowledge of genes involved in renal processes from biomedical research using the Gene Ontology'.
NIH grant number 2U01HG02712-04: UniProtKB Consortium

Previous Funding:

European Union grant number QLRI-CT-2001000015: TEMBLOR - The European Molecular Biology Linked Original Resources
European Union grant number QLRT-CT-2001-00981; BioBabel- Enhanced Interoperability of Biological Databases by Standardisation of Biochemical Terminology and Introduction of a Shared Ontology
BBSRC Tools and Resources Fund grant (BB/E023541/1) 'Further development of the QuickGO web interface for browsing and retrieving Gene Ontology Annotation Data'.

GOA is also grateful to the developers and curators from the GO Consortium and GO associate member databases.