Gene Ontology Annotation (UniProt-GOA) Database
The UniProt GO annotation program aims to provide high-quality Gene Ontology (GO) annotations to proteins in the UniProt Knowledgebase (UniProtKB). The assignment of GO terms to UniProt records is an integral part of UniProt biocuration . UniProt manual and electronic GO annotations are supplemented with manual annotations supplied by external collaborating GO Consortium groups, to ensure a comprehensive GO annotation dataset is supplied to users .
UniProt is a member of the GO Consortium .
For fast access to the Gene Ontology terms and annotations, please use our QuickGO browser.
Release cycle
All UniProt-GOA Gene Association Files are released approximately every four weeks and can be accessed from our Downloads page. We aim to coordinate our release with the UniProtKB releases . In addition, we release our human and chicken Gene Association Files every two weeks to enable the GO Consortium Reference Genome project to use our most up-to-date annotations for curation of orthologous species. These interim releases can be downloaded from our ftp site .
Latest UniProt-GOA news
All the latest news and information relating to UniProt-GOA.
| Date | UniProt-GOA News |
|---|---|
| 18 September, 2013 | As of our previous release, dated 24th July 2013, we have rationalized the attribution display for UniProt- and Ensembl-created annotations. This attribution is shown in the 'assigned_by' column, which is column 15 of the Gene Association Files (GAF) and column 10 of the Gene Product Assocation Data files (GPAD). UniProt-created annotations all now have the attribution 'UniProt', this includes UniProt manual annotation and automatic annotation based on EC, HAMAP, UniProt keywords, UniProt subcellular location and UniPathway. Ensembl-created annotations all now have the attribution 'Ensembl', this includes the automatic annotation from Ensembl vertebrates, EnsemblFungi and EnsemblPlants/Gramene. |
Funding
Current Funding:
- EMBL
- NIH-NHGRI [1U41HG006104-03]: UniProtKB Consortium
- National Human Genome Research Institute (NHGRI) [5P41HG002273-09]: Gene Ontology Consortium
- British Heart Foundation grant [SP:07/007/23671] 'The Integration of the knowledge if genes involved in heart development and cardiovascular processes from biomedical research, using
standardised Gene Ontology'
Previous Funding:
- Kidney Research UK Project Grant RP26/2008 - 'Integration of knowledge of genes involved in renal processes from biomedical research using the Gene Ontology'.
- European Union grant number QLRI-CT-2001000015: TEMBLOR - The European Molecular Biology Linked Original Resources
- European Union grant number QLRT-CT-2001-00981; BioBabel- Enhanced Interoperability of Biological Databases by Standardisation of Biochemical Terminology and Introduction of a Shared Ontology
- BBSRC Tools and Resources Fund grant (BB/E023541/1) 'Further development of the QuickGO web interface for browsing and retrieving Gene Ontology Annotation Data'.
UniProt-GOA is also grateful to the developers and curators from the GO Consortium and GO associate member databases.