Bacteria Genomes - SALMONELLA ENTERICA

Salmonellae are members of the family Enterobacteriaceae, including Escherichia species and the closely related species Shigella. Salmonella enterica serovar Typhi (S. typhi) has, as opposed to other species of the genus, no animal reservoir. It is strictly a human pathogen and is spread by the fecal-oral route by asymptomatic carriers. Salmonella typhi is a flagellated, Gram-negative bacillus.

Salmonella enterica serovar typhi is the aetiological agent of typhoid fever, a serious invasive bacterial disease of humans with an annual global burden of approximately 16 million cases, leading to 600,000 fatalities.Many S. enterica serovars actively invade the mucosal surface of the intestine but are normally contained in healthy individuals by the local immune defence mechanisms. However, S.enterica typhi has evolved the ability to spread to the deeper tissues of humans, including liver, spleen and bone marrow. After ingestion, the organisms multiply in the small intestine, then invade through the intestinal wall and are carried to the regional lymph nodes. From there they are spread to other organs.

References:

http://www.ebi.ac.uk/integr8/QuickSearch.do?action=doOrgSearch&organismName=Salmonella+enterica
http://www.worldwidevaccines.com/indexm.asp
http://www.sanger.ac.uk/Projects/S_typhi/