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Genes & Disease - Emerging infectious diseases - Swine Flu

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About Influenza A Virus:

Swine Flu
Influenza A virus (H1N1) was detected in Mexico during April 2009. Flu viruses mutate over time causing changes to the structure of surface proteins called antigens. If people or animal have been exposed to these changes in the surface structure of a virus, they are likely to have acquired some immunity. On the other hand, if the antigens are new, their immune response will be weakened.

Influenza A virus (strain H1N1) is the same strain that causes seasonal outbreaks in humans on a regular basis. However, the version of the virus that is causing the present alert carries genetic modifications that enable it to jump from one species to another. This is a very rare event. Earlier version of this strain of the virus, caused the pandemic known as the Spanish Flu in 1918 (Flu names are usually associated with the country in which the infection was first detected).

Flu virus infections can be treated. Usually mixed doses of antiviral drugs, such as Tamiflu and Relenza. At the time of writing a vaccine is not available for this particular train of the virus.

Information about Swine Flu: The following links provide access to data contained within EMBL-EBI database in relation to the genomic sequencing of this particular strain of the virus:

Nucleotide sequences:


EMBL-Bank (Updates in May 2009)
http://www.ebi.ac.uk/ebisearch/search.ebi?db=emblnew_standard&t=creation_date%3A(0?-may-2009)+description%3A(%22influenza+A+virus%22)

All EMBL-Bank sequences since April 2009 (in SRS):
http://srs.ebi.ac.uk/cgi-bin/wgetz?-id+bla+-view+EMBLSeqSimpleView+[EMBLNew-crd:20090401:20090530]&[emblnew-des:influenza&virus]

GenBank (NCBI):

http://www.ncbi.nlm.nih.gov/genomes/FLU/SwineFlu.html

Protein Sequences:

UniProt:
http://www.uniprot.org/uniprot/?query=influenza+A+virus+h1n1&sort=score

Protein Structures:


PDBe:
http://www.ebi.ac.uk/ebisearch/search.ebi?db=pdbe&t=influenza+virus+h1n1

Ontologies:


Taxonomy:
http://www.ebi.ac.uk/ebisearch/search.ebi?db=taxonomy&t=h1n1

[these links will be updated regularly in the course of the next weeks]

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